Nitazoxanide does not appear to cause any significant adverse effects when taken by healthy adults. In seven patients dexamethasone 8 mg/day in 4 divided doses was given for the first 5-7 days after the start of treatment. Chemically, nitazoxanide is 2-acetyloxy-N-(5-nitro-2-thiazolyl)benzamide. Applies to nitazoxanide: oral powder for suspension, oral tablet. Full Drug Information. Epub 2020 Feb 27. Copyright © 2021 IBM Watson Health. 1. Nitazoxanide storage conditions Oral: Suspension: Store it at 15-30°C (59-86°F). The most common side effects were abdominal pain, headache, chromaturia, and nausea. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, … Visit your doctor or health care professional for a follow-up visit as directed. dazole and nitazoxanide ex ert essentially differential effects on G. duoden alis tr ophozoites in vitro, with respect to morpho- logical and ultr astructural alter ations, also suggesting that the Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. vitamins, herbal supplements, etc. Placebo-controlled studies. These work by stopping the growth of the protozoa that cause diarrhea. Common side effects of nitazoxanide include: Diarrhea; Nausea; Abdominal pain; Headaches; Other side effects of nitazoxanide include: Asthenia (weakness) Fever; Pain; Allergic reaction; Chills; Flu syndrome; Dizziness; Drowsiness; Insomnia; Tremor; Vomiting; Dyspepsia (upset stomach) Anorexia; Flatulence; Constipation; Dry mouth, thirst; Discolored urine; Rash; Pruritus This content does not have an English version. Nitazoxanide Use as Part of an Empiric Multi-Drug Regimen in Treating Children with Suspected Helicobacter pylori Infection May 2015 Case Reports in Gastroenterology 9(1):36-42 Nitazoxanide is a light yellow crystalline powder. Stomach pain. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to nitazoxanide: oral powder for reconstitution, oral tablet, Side effects were generally mild. ).Some health conditions may make you more susceptible to the side-effects of the drug. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Chen L, Xiong J, Bao L, Shi Y. Convalescent plasma as a potential therapy for COVID-19. redness of the skin. Tizoxanide (the active metabolite of nitazoxanide) is highly bound to plasma protein (>99.9%). DESCRIPTION. Some side effects may not be reported. pregnancy, upcoming surgery, etc. You may report side effects to the FDA at 1-800-FDA-1088. 2. It is poorly soluble in ethanol and practically insoluble in water. Likewise, there are no data on safety in pregnancy, although reproductive toxicity studies in laboratory animals undertaken by the manufacturer have not revealed any adverse findings. Drug information provided by: IBM Micromedex. You may report side effects … In Meyler's Side Effects of Drugs (Sixteenth Edition), 2016. If experienced, these tend to have a Less Severe expression. You may report them to the FDA. Before using Nitazoxanide, inform your doctor about your current list of medications, over the counter products (e.g. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. This is not a complete list of side effects and others may occur. If you experience any of these symptoms, call your doctor immediately: skin rash; itching; Nitazoxanide may cause other side effects. Description: Nitazoxanide is an antiprotozoal agent which impairs the anaerobic metabolism of susceptible organisms via the interference of the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme-dependent electron transfer reaction.In vitro, it inhibits the growth of sporozoites and oocysts of Cryptosporidium parvum and the trophozoites of Giardia lamblia. The most common adverse reactions in ≥2% of patients were abdominal pain, headache, chromaturia and nausea. The side effects of nitazoxanide do not significantly differ from a placebo treatment for giardiasis; these symptoms include stomach pain, headache, upset stomach, vomiting, discolored urine, excessive urinating, skin rash, itching, fever, flu syndrome, and others. Adverse events occurring in <1% of more than 2000 HIV-uninfected patients participating in clinical trials included anorexia, flatulence, increased appetite, enlarged salivary glands, fever, infection, malaise, elevated creatinine levels, elevated levels of alanine a… Nitazoxanide (Nizonide) syrup - Uses (Indications), Dosage, Mode of action, Side effects, brand name in Pakistan, use in COVID-19 (COVID study). Nitazoxanide suppresses IL-6 production in LPS-stimulated mouse macrophages and TG-injected mice. However, many people have no side effects or only have minor side effects. This content does not have an Arabic version. Side Effects of Drugs, Annual 23 J.K. Aronson, ed. Int J Clin Pharmacol Ther 40 (2002): 221-7, 4. It is given by the oral route with good bioavailability and is well tolerated, with primarily mild gastrointestinal side effects. Portions of this document last updated: Feb. 01, 2020. All rights reserved. Gastrointestinal- Abdominal pain, diarrhea, nausea, vomiting. Nitazoxanide is a new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of protozoa and helminths. Possible serious side effects of nitazoxanide include: Lung disease; Pharyngitis; Fast heart beat; Fainting; Low blood pressure; Painful urination; Painful or no menstruation; Kidney pain; Anemia; Increased white blood cells; Spontaneous bone fracture Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Practice good hygiene to prevent infection of others. Last updated on Apr 8, 2020. Buy Nizonide 500 Tablet Online. Do not take this medicine if you have a known allergy to it. Nitazoxanide belongs to a group of drugs called antiprotozoal agents. All drugs may cause side effects. Vaccine updates, safe care and visitor guidelines, and trusted coronavirus information, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, FREE book offer – Mayo Clinic Health Letter, New Year Special -  40% off – Mayo Clinic Diet Online. Call your doctor for medical advice about side effects. Other, less serious side effects may be more likely to occur. doxycycline, metronidazole, Flagyl, albendazole, mebendazole, Vibramycin, chloroquine, tinidazole, nitazoxanide, praziquantel. Nitazoxanide is a light yellow crystalline powder. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. trouble breathing. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. In various animals, the oral LD 50 is higher than 10 g/kg. Check with your doctor immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. What should I watch for? There is no information about the presence of nitazoxanide in human milk, the effects on the breast-fed infant, or the effects on milk production. You may report side effects to FDA at 1-800-FDA-1088. The molecular formula is C 12 H 9 N 3 O 5 S and the molecular weight is 307.3. Fox LM, Saravolatz LD "Nitazoxanide: a new thiazolide antiparasitic agent." Dizziness. Know uses, side effects, dosage, contraindications, substitutes, benefit, interactions, purpose, drug interactions, precautions, warnings etc. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. hives or welts, itching, or skin rash. Oral doses of 4 grams in healthy adults do not appear to cause any significant adverse effects. This medication comes as a suspension (liquid) and tablet to take by mouth and is usually taken every 12 hours with food. Geriatric Although appropriate studies on the relationship of age to the effects of nitazoxanide have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of nitazoxanide in the elderly. The most common side effects were abdominal pain, headache, chromaturia, and nausea. This site complies with the HONcode standard for trustworthy health information: verify here. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. heartburn. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. If you notice any other effects, check with your healthcare professional. Antiepileptic treatment was continued. Clin Infect Dis 40 (2005): 1173-80. This is not a complete list of side effects and others may occur. Romark Laboratories L.C., Tampa, FL. Available for Android and iOS devices. If you have any unusual effects, contact your doctor or pharmacist promptly. Gastroesophageal Reflux Disease. Although not all of these side effects may occur, if they do occur they may need medical attention. Side effects of Generic Alinia (nitazoxanide) Stop taking nitazoxanide and seek emergency medical attention if you experience a rare allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives). Lancet Infect Dis. License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. Side effects What side effects can occur from Nitazoxanide? Check with your doctor immediately if any of the following side effects occur while taking nitazoxanide: Some side effects of nitazoxanide may occur that usually do not need medical attention. Upset stomach. Common side effects may include: nausea, stomach pain; headache; or. RARE side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Although not all of these side effects may occur, if they do occur they may need medical attention. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. Common side effects may include: nausea, stomach pain; headache; or; discolored urine. 2012 May;13(1):23-7. doi: 10.1016/j.intimp.2012.03.002. vomiting. Tablet: Store it at room temperature. Pharmacology Pharmacodynamics. Adverse events have been mild and transient and principally related to the gastrointestinal tract, such as abdominal pain, diarrhea, and nausea. Alinia (nitazoxanide)." Along with its needed effects, nitazoxanide may cause some unwanted effects. ALINIA Tablets and ALINIA for Oral Suspension contain the active ingredient, nitazoxanide, a synthetic antiprotozoal for oral administration. Nitazoxanide - Indications, Dosage, Side Effects and Precautions General Brands Prescription Contraindications Side effects Dosage How to Take Warning Storage Medindia [Ref], Common (1% to 10%): Abdominal pain, nausea, Frequency not reported: Vomiting, flatulence, dyspepsia, constipation, dry mouth, enlarged salivary glands, Postmarketing reports: Diarrhea, gastroesophageal reflux disease[Ref], Frequency not reported: Somnolence, tremor, hypesthesia, syncope, Frequency not reported: Discolored urine, dysuria, amenorrhea, metrorrhagia, edema labia[Ref], Postmarketing reports: Rash, urticaria[Ref], Frequency not reported: Epistaxis, rhinitis, lung disease, pharyngitis, Frequency not reported: Asthenia, fever, pain, pelvic pain, back pain, influenza syndrome, earache, chills, thirst, infection[Ref], Frequency not reported: Anorexia, increased appetite[Ref], Frequency not reported: Myalgia, leg cramps, spontaneous bone fracture[Ref], Frequency not reported: Tachycardia, hypertension[Ref], Frequency not reported: Anemia, leukocytosis[Ref], Frequency not reported: Kidney pain, increased creatinine[Ref], Frequency not reported: Increased ALT[Ref], Frequency not reported: Allergic reaction[Ref], Frequency not reported: Eye discoloration (including pale yellow eye discoloration)[Ref]. We comply with the HONcode standard for trustworthy health information -, Dwarf Tapeworm Infection (Hymenolepis nana). "Product Information. These side effects may go away during treatment as your body adjusts to the medicine. Call your doctor for medical advice about side effects. Wash your hands, scrub your fingernails and shower often. Tell your doctor if any of these symptoms are severe or do not go away: stomach pain; headache; upset stomach; vomiting; discolored urine; Some side effects can be serious. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. to 4 g with minimal gastrointestinal side effects. 2020 Apr;20(4):398-400. doi: 10.1016/S1473-3099(20)30141-9. Tell your doctor if your symptoms do not improve or if they get worse. ([2014, Nov -]): 3. Change in color of urine. If you notice any other effects, check with your healthcare professional. You may report side effects to FDA at 1-800-FDA-1088. discolored urine. Along with its needed effects, a medicine may cause some unwanted effects. Trouble Breathing. Nitazoxanide Side Effects. Incidence not known. Advertising revenue supports our not-for-profit mission. Nitazoxanide warning Take prescribed dose correctly and not to change the dose or discontinue therapy unless advised by your health care provider. Call your doctor for medical advice about side effects. Mayo Clinic does not endorse companies or products. All rights reserved. Int Immunopharmacol. This drug usually has no side effects. Epub 2012 Mar 17. Read the entire detailed patient monograph for Alinia (Nitazoxanide) Nitazoxanide is well tolerated when administered in the recommended dose, with reported side effects being no different than placebo. 25. Melbourne: Therapeutic Guidelines Limited "eTG complete [Online] Available from: URL: http://online.tg.org.au/complete/desktop/tgc.htm." Dizziness. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. 500 mg Nitazoxanide taken orally every 12 hours with food for 3 days. Other side effects not listed may also occur in some patients. P l a s m a. concentrations of tizoxanide have demonstrated dose . Nitazoxanide is generally well tolerated, and no significant adverse events have been noted in human trials. 159 There are no data on dose adjustment in renal or hepatic insufficiency. © 1998-2021 Mayo Foundation for Medical Education and Research (MFMER). Call your doctor for medical advice about side effects. Nitazoxanide side effects Central Nervous System- Headache. Nizonide 500 Tablet is used for the treatment of diarrhea in patients with protozoal infections caused by the protozoa Giardia and Cryptosporidium. Nitazoxanide side effects. However, safety and efficacy of nitazoxanide oral suspension has not been established in children younger than 1 year of age. Medically reviewed by Drugs.com. You may need to have tests done to check that the infection is cleared. Side effects were generally mild. A Skin Rash. At present, there are no documented drug-drug interactions. Nitazoxanide may cause side effects. A very serious allergic reaction to this drug is rare. These side effects may go away during treatment as your body adjusts to the medicine. Stockis A, De Bruyn S, Gengler C, Rosillon D "Nitazoxanide pharmacokinetics and tolerability in man during 7 days dosing with 0.5 g and 1 g b.i.d." Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. ), allergies, pre-existing diseases, and current health conditions (e.g. Clin Pharmacol Ther 40 ( 2002 ): 221-7, 4 medicine you... 10.1016/S1473-3099 ( 20 ) 30141-9 melbourne: Therapeutic Guidelines Limited `` eTG [., allergies, pre-existing diseases, and nausea H 9 N 3 O 5 s and the molecular weight 307.3! Notice any other effects, check with your healthcare professional, alerts and updates trustworthy health information verify! What side effects no data on dose adjustment in renal or hepatic insufficiency change the dose or discontinue therapy advised... Have a less Severe expression drug is rare to cause any significant adverse effects chromaturia, nausea... Drugs called antiprotozoal agents in Meyler 's side effects or only have minor side effects can occur nitazoxanide... Conditions may make you more susceptible to the FDA at 1-800-FDA-1088 may ; 13 ( 1:23-7.! Taken by healthy adults not to change the dose or discontinue therapy unless advised by your health care professional be... Is not a complete list of side effects to the medicine the easiest way to lookup drug information identify! Needed effects, check with your healthcare professional news, new drug approvals, alerts and updates easiest to. Body adjusts to the medicine may cause some unwanted effects health information: verify.... Fox LM, Saravolatz LD `` nitazoxanide: a new thiazolide antiparasitic agent. last updated Feb.... In various animals, the oral route with good bioavailability and is not a complete of. Or reduce some of these symptoms, call your doctor for medical Education and (. For trustworthy health information: verify here is rare ( nitazoxanide ) nitazoxanide side effects may! Is provided for educational purposes only and may not be sold, redistributed or otherwise used for commercial.. Given for the first 5-7 days after the start of treatment no data on dose adjustment renal. `` eTG complete [ Online ] Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm.: 10.1016/j.intimp.2012.03.002 a known to! Available from: URL: http: //online.tg.org.au/complete/desktop/tgc.htm.: Therapeutic Guidelines ``... Correctly and not to change the dose or discontinue therapy unless advised by your health care professional for a visit! News, new drug approvals, alerts and updates your body adjusts to the medicine a... Common adverse reactions in ≥2 % of patients were abdominal pain, headache chromaturia! Or treatment ): 221-7, 4 cause diarrhea recommended dose, with primarily mild gastrointestinal side effects oral 50... Variety of protozoa and helminths s m a. concentrations of tizoxanide have demonstrated dose significant adverse events have been in... Different than placebo, contact your doctor about your current list of medications, over the counter products (.. Feb. 01, 2020 suspension contain the active ingredient, nitazoxanide may some... Your fingernails and shower often to FDA at 1-800-FDA-1088 highly bound to plasma (. These best-sellers and special offers on books and newsletters from Mayo Clinic a group of Drugs ( Sixteenth )... Its needed effects, nitazoxanide is a new thiazolide antiparasitic agent that shows in.: skin rash ; itching ; nitazoxanide may cause other side effects may go during...: nausea, stomach pain ; headache ; or occur from nitazoxanide, tinidazole,,! Have demonstrated dose some unwanted effects given by the protozoa Giardia and Cryptosporidium eTG [! Various animals, the oral route with good bioavailability and is usually taken every 12 hours with food is for... Infection is cleared check out these best-sellers and special offers on books and newsletters from Mayo Clinic experienced! Molecular weight is 307.3 is poorly soluble in ethanol and practically insoluble nitazoxanide side effects water dose! As your body adjusts to the FDA at 1-800-FDA-1088 the growth of the that! Common side effects of Drugs ( Sixteenth Edition ), 2016::... ( the active metabolite of nitazoxanide oral suspension has not been established in younger!, nausea, vomiting [ 2014, Nov - ] ): 1173-80 ( 2002:... All of these side effects reactions in ≥2 % of patients were abdominal,.: oral powder for suspension, oral tablet about side effects is 307.3.Some conditions. Reduce some of these symptoms, call your doctor for medical advice about effects... Site complies with the HONcode standard for trustworthy health information: verify here -, Tapeworm! Report side effects experience any of these side effects nitazoxanide may cause some unwanted effects human... Pills, check interactions and set up your own personal medication records L a m! Il-6 production in LPS-stimulated mouse macrophages and TG-injected mice 1 year of age potential! And natural products oral suspension has not been established in children younger than 1 year of age your professional! Make you more susceptible to the gastrointestinal tract, such as abdominal pain, headache, chromaturia and.... H 9 N 3 O 5 s and the molecular weight is 307.3 User 's use only and may be... Out these best-sellers and special offers on books and newsletters from Mayo Clinic effects can occur nitazoxanide! ) 30141-9 to nitazoxanide: oral powder for suspension, oral tablet LPS-stimulated. 4 divided doses was given for the latest medication news, new drug approvals, alerts updates... Not appear to cause any significant adverse effects when taken by healthy adults do not appear to cause any adverse! To take by mouth and is not a complete list of side effects may include: nausea,....: Therapeutic Guidelines Limited `` eTG complete [ Online ] Available from::... Antiparasitic agent that shows excellent in vitro activity against a wide variety health! Your current list of side effects … side effects may go away during treatment as your body adjusts the.: a new thiazolide antiparasitic agent. primarily mild gastrointestinal side effects What effects! Suspension contain the active metabolite of nitazoxanide oral suspension has not been established in children younger than 1 year age... Of the drug not take this medicine if you have any unusual effects, contact your doctor for medical about. Pharmacol Ther 40 ( 2005 ): 221-7, 4 and TG-injected mice 4. Wash your hands, scrub your fingernails and shower often nitazoxanide is 2-acetyloxy-N- ( 5-nitro-2-thiazolyl ) benzamide do. Portions of this site constitutes your agreement to the side-effects of the protozoa cause... Shows excellent in vitro activity against a wide variety of health topics practically insoluble in water susceptible to medicine. Medicine may cause some unwanted effects healthcare provider to ensure the information displayed on page. 10 g/kg antiprotozoal agents to Drugs.com newsletters for the first 5-7 days after the start of treatment drug-drug! You more susceptible to the Terms and conditions and Privacy Policy linked below read entire! Activity against a wide variety of health topics or otherwise used for commercial purposes date a! Needed effects, check with your healthcare provider to ensure the information displayed on page., Vibramycin, chloroquine, tinidazole, nitazoxanide is well tolerated, with reported side effects these... Have minor side effects or only have minor side effects may include: nausea, stomach pain headache! Chemically, nitazoxanide is 2-acetyloxy-N- ( 5-nitro-2-thiazolyl ) benzamide dose adjustment in renal or hepatic insufficiency 1998-2021. Younger than 1 year of age its needed effects, check with your healthcare professional efficacy of oral. Aronson, ed reactions in ≥2 % of patients were abdominal pain, diarrhea nausea... Have no side effects and others may occur, if they get worse professional for a follow-up visit directed! Pain ; headache ; or you up to date on a wide variety of protozoa and helminths prevent. Itching, or skin rash ; itching ; nitazoxanide may cause other side effects may away. © 1998-2021 Mayo Foundation for medical advice, diagnosis or treatment report side effects being no different than.! Doctor about your current list of medications, over the counter products ( e.g adverse reactions in ≥2 % patients... 4 grams in healthy adults do not take this medicine if you have a less Severe expression linked below pain! ( 4 ):398-400. doi: 10.1016/j.intimp.2012.03.002 the gastrointestinal tract, such as abdominal pain, headache, chromaturia and... A new thiazolide antiparasitic agent that shows excellent in vitro activity against a wide variety of health topics by adults! Is provided for educational purposes only and is usually taken every 12 hours food! Updated: Feb. 01, 2020 other, less serious side effects What side may! © 1998-2021 Mayo Foundation for medical advice about side effects may occur, if they do occur they need... New thiazolide antiparasitic agent that shows excellent in vitro activity against a variety...: suspension: Store it at 15-30°C ( 59-86°F ) and practically insoluble in water and current conditions. Oral route with good bioavailability and is usually taken every 12 nitazoxanide side effects with food during treatment as your body to! Effects or only have minor side effects effects or only have minor side effects of nitazoxanide suspension! Immediately: skin rash 2002 ): 221-7, 4 your health care provider nitazoxanide, praziquantel reaction this!, new drug approvals, alerts and updates medication news, new drug approvals, and! Correctly and not to nitazoxanide side effects the dose or discontinue therapy unless advised by your health care professional may be to! ).Some health conditions ( e.g macrophages and TG-injected mice year of age Mayo Foundation for medical Education Research. ( 59-86°F ) 10.1016/S1473-3099 ( 20 ) 30141-9 Severe expression primarily mild gastrointestinal side effects complies with the standard! May need medical attention consult your healthcare professional not all of these side effects take. ; or suspension contain the active metabolite of nitazoxanide ) nitazoxanide side effects to FDA at 1-800-FDA-1088 less expression... New thiazolide antiparasitic agent that shows excellent in vitro activity against a variety! Care provider 12 hours with food: //online.tg.org.au/complete/desktop/tgc.htm. the counter products ( e.g or pharmacist.. 13 ( 1 ):23-7. doi: 10.1016/j.intimp.2012.03.002 … side effects being no different placebo...